Sure. If you have too much gear for the combo, you are wasting torque. I know a guy running a 4.86 gear with a nitrous motor and I swear if he went down to a 4.11 or 4.33 he would be faster. I've been in the car with him and you can tell the motor is just winding through the gears and all that torque the nitrous is making is being wasted.