Gotta run some sort of pressurized lube lifters, a cam button or thrust plate & keep the specs reasonable so spring pressure isn't ridiculous. If you don't want to mess with special distributor gears, you can get either an austempered ductile iron core or a steel core with an iron gear. Remember to use a bronze tipped fuel pump pushrod for austempered cores with a high pressure/high volume fuel pump. Some guys will say to only use a steel core, some say it's OK with mild lobes & spring pressures. I have a Comp Cams XR280R with the austempered core, Comp Cams Endure-X lifters & Isky Tool Room springs. My engine builder says it will be just fine.
Tommy